Normalization of testosterone level is associated with reduced risk of heart...
The effects of testosterone replacement therapy on cardiovascular outcomes such as heart attack and stroke are controversial and have been generating heated discussions among clinicians as well as...
View ArticleNormalization of testosterone level is associated with reduced incidence of...
Normalization of testosterone level is associated with reduced incidence of myocardial infarction and mortality in men. Sharma R, Oni OA, Gupta K, et al. Eur. Heart J. 2015:Aug 6 [Epub ahead of...
View ArticleCritical Update of the 2010 Endocrine Society Guidelines for Hypogonadism
Critical Update of the 2010 Endocrine Society Clinical Practice Guidelines for Male Hypogonadism: A Systematic Analysis. Seftel AD, Kathrins M, Niederberger C. Mayo Clin Proc. 2015; 90(8): 1104-1115.In...
View ArticleEffects of Testosterone Administration for 3 Years on Subclinical...
Effects of Testosterone Administration for 3 Years on Subclinical Atherosclerosis Progression in Older Men With Low or Low-Normal Testosterone Levels: A Randomized Clinical Trial. Basaria S, Harman SM,...
View ArticleTestosterone Replacement Therapy and Mortality in Older Men
Testosterone Replacement Therapy and Mortality in Older Men. Hackett GI. Drug Saf. 2015 Oct 19.Despite a large prevalence of hypogonadism and increased testosterone prescribing over the past decade,...
View ArticleTestosterone Therapy Reduces Insulin Resistance and Inflammation in Men with...
Insulin Resistance and Inflammation in Hypogonadotropic Hypogonadism and Their Reduction After Testosterone Replacement in Men With Type 2 Diabetes. Dhindsa S, Ghanim H, Batra M, et al. Diabetes Care....
View ArticleEffects of testosterone treatment in older men
Medical research can be of varying quality. The double-blind randomized controlled trial (RCT) is accepted by medicine as the gold standard objective scientific methodology, and provides the highest...
View ArticleTestosterone levels, testosterone therapy and all-cause mortality in men with...
Serum testosterone, testosterone replacement therapy and all-cause mortality in men with type 2 diabetes: retrospective consideration of the impact of PDE5 inhibitors and statins. Hackett G, Heald AH,...
View ArticleEffects of Testosterone Therapy for up to 10 years on Obesity and Metabolic...
Effects of continuous long-term testosterone therapy (TTh) on anthropometric, endocrine and metabolic parameters for up to 10 years in 115 hypogonadal elderly men: real-life experience from an...
View ArticleSurvival and cardiovascular events in men treated with testosterone
Survival and cardiovascular events in men treated with testosterone replacement therapy: an intention-to-treat observational cohort study. Wallis CJD, Lo K, Lee Y, et al. The Lancet Diabetes &...
View ArticleAUA Congress Report– new studies on long-term testosterone therapy
The American Urological Association (AUA) is a premier urologic association, which provides the global urology community opportunities to present, learn and share news of discovery and advancement. In...
View ArticleReal-life data - men with testosterone deficiency and a history of...
Men with testosterone deficiency and a history of cardiovascular diseases benefit from long-term testosterone therapy: observational, real-life data from a registry study. Vascular health and risk...
View ArticleTestosterone Deficiency and Treatment - International Expert Consensus...
Fundamental Concepts Regarding Testosterone Deficiency and Treatment: International Expert Consensus Resolutions. Morgentaler A, Zitzmann M, Traish AM, et al. Mayo Clin. Proc....
View ArticleWaist-to-height ratio as screening tool for testosterone deficiency and...
A common belief is that testosterone deficiency is an “old man’s issue”. This is very wrong. Actually, an excess amount of body fat can cause a man’s testosterone levels to drop as much as 10 years of...
View ArticleDispelling the myth of testosterone treatment and prostate cancer
Testosterone treatment is not associated with increased risk of prostate cancer or worsening of lower urinary tract symptoms: prostate health outcomes in the Registry of Hypogonadism in Men. Debruyne...
View ArticleTestosterone Therapy in Men with Prostate Cancer – new research
Testosterone Therapy in Patients with Treated and Untreated Prostate Cancer: Impact on Oncologic Outcomes. Ory J, Flannigan R, Lundeen C, Huang JG, Pommerville P, Goldenberg SL. J Urol....
View ArticleTestosterone treatment is not associated with risk of adverse cardiovascular...
Testosterone treatment is not associated with increased risk of adverse cardiovascular events: results from the Registry of Hypogonadism in Men (RHYME). Maggi M, Wu FC, Jones TH, et al. Int J Clin...
View ArticleAACE and ACE Clinical Practice Guidelines on Obesity Call for Testosterone...
American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for Comprehensive Medical Care of Patients with Obesity, 2016.The combined...
View ArticleLong-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces...
Long-Term Testosterone Therapy Improves Cardiometabolic Function and Reduces Risk of Cardiovascular Disease in Men with Hypogonadism: A Real-Life Observational Registry Study Setting Comparing Treated...
View ArticleEffects of testosterone treatment on body fat, lean mass, symptoms and leptin...
Ng Tang Fui M, Prendergast LA, Dupuis P, et al. Effects of testosterone treatment on body fat and lean mass in obese men on a hypocaloric diet: a randomised controlled trial. BMC medicine....
View ArticleIs there a protective role of testosterone against high-grade prostate cancer?
Historically, testosterone has almost been a synonym for prostate cancer, and therefore many men have been - and still are - denied testosterone therapy, despite having testosterone deficiency.A...
View ArticleEffects of Testosterone Therapy for 3 Years on Muscle Performance and...
Declining testosterone levels – which is commonly seen in men as they get older - are associated with reduced lean body mass, muscle strength, physical function and performance. Evidence for a...
View ArticleTestosterone treatment and risk of blood clots - what is new?
In discussions about side effects of testosterone treatment, prostate cancer and heart disease get most attention. However, as we have described in several study reports published here in the “Research...
View ArticleHematocrit elevation following testosterone therapy – does it increase risk...
Ohlander SJ, Varghese B, Pastuszak AW. Erythrocytosis Following Testosterone Therapy. Sex Med Rev. 2017 [May 16, Epub ahead of print]In discussions about side effects of testosterone treatment,...
View ArticleTestosterone levels and anemia in older men
Anemia is a common concern among the elderly; after the age of 50 years, anemia prevalence increases rapidly, especially in men. In community studies, the prevalence of anemia in older men has been...
View ArticleCould testosterone therapy in hypogonadal men ameliorate anemia, a...
Could Testosterone Replacement Therapy in Hypogonadal Men Ameliorate Anemia, a Cardiovascular Risk Factor? An Observational, 54-Week Cumulative Registry Study. Zhang LT, Shin YS, Kim JY, Park JK. J...
View ArticleEffective testosterone treatment reduces incidence of atrial fibrillation
Sharma, R., et al., Normalization of Testosterone Levels After Testosterone Replacement Therapy Is Associated With Decreased Incidence of Atrial Fibrillation. J Am Heart Assoc, 2017. 6(5)While the...
View ArticleEffect of Testosterone Treatment and Exercise on Muscle Wasting in Patients...
Dos Santos MR, Sayegh AL, Bacurau AV, et al. Effect of Exercise Training and Testosterone Replacement on Skeletal Muscle Wasting in Patients With Heart Failure With Testosterone Deficiency. Mayo Clin...
View ArticleUK policy statements on testosterone deficiency
Hackett G, Kirby M, Edwards D, Jones TH, Rees J, Muneer A. UK policy statements on testosterone deficiency. Int J Clin Pract. 2017;71(3-4).Testosterone deficiency (also known as hypogonadism) and its...
View ArticleLow Testosterone is Associated with Elevated Cardiovascular Disease Biomarkers
Pastuszak AW, Kohn TP, Estis J, Lipshultz LI. Low Plasma Testosterone Is Associated With Elevated Cardiovascular Disease Biomarkers. The journal of sexual medicine. 2017;14(9):1095-1103.The fear of...
View ArticleLong-Term Testosterone Therapy Improves Urinary and Sexual Function and...
STUDY: Haider KS, Haider A, Doros G, Traish A. Long-Term Testosterone Therapy Improves Urinary and Sexual Function, and Quality of Life in Men with Hypogonadism: Results from a Propensity Matched...
View ArticleEffectiveness and tolerability of injectable testosterone undecanoate
Wolf J, Keipert D, Motazedi H, Ernst M, Nettleship J, Gooren L. Effectiveness and tolerability of parenteral testosterone undecanoate: a post-marketing surveillance study. The Aging Male: the official...
View ArticleRemission of type 2 diabetes in a hypogonadal man after long-term...
STUDY: Haider A, Haider KS, Saad F. Remission of type 2 diabetes in a hypogonadal man under long-term testosterone therapy. Endocrinology, diabetes & metabolism case reports. 2017; Sept 14.The...
View ArticleImproved beta-cell function after treatment with testosterone undecanoate
STUDY: Dimitriadis GK, Randeva HS, Aftab S, et al. Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone...
View ArticleBenefits of Testosterone Therapy in Men with Testosterone Deficiency
The most widely known effect of testosterone therapy is improved sexual function. But testosterone therapy actually has a wide range of physiological effects in men, including increased muscle mass,...
View ArticleClinical Practice Guidelines on Diagnosis and Treatment of Hypogonadism –...
Clinical practice guidelines on hypogonadism and testosterone therapy aim to help clinicians diagnose and treat men who present with hypogonadism. However, due to lack of scientific data on several...
View ArticleEffect of testosterone therapy on insulin resistance, glycemic control,...
Occasionally a concern about testosterone therapy is heart disease risk. New medical research data is rapidly accumulating, showing that testosterone therapy – in contrast to what is sometimes believed...
View ArticleEffect of Testosterone Therapy on Bone Mineral Density and Bone Strength in...
Low bone mineral density is a prevalent and treatable cause of osteoporosis and its associated morbidity and mortality in men with hypogonadism. The Bone Trial of the Testosterone Trials - a series of...
View ArticleHypogonadism, Muscle Weakness, and Multi-morbidity in Men
Hypogonadism (testosterone deficiency) is more common than previously thought, even in younger men. Men with hypogonadism – regardless of age – have a higher prevalence of muscle weakness and...
View ArticleHypogonadism, Muscle Weakness, and Multimorbidity in Men
Hypogonadism (testosterone deficiency) is more common than previously thought, even in younger men. Men with hypogonadism – regardless of age – have a higher prevalence of muscle weakness and...
View ArticleChanges in testosterone levels within individuals and risk of prostate cancer...
A long-held belief is that high testosterone levels increase risk of prostate cancer. To the contrary, most studies show that it is low testosterone that increases risk of prostate cancer. Furthermore,...
View ArticleHypogonadism and testosterone treatment following stroke in men with type 2...
A new study was recently published in The Aging Male which treated hypogonadal patients with type 2 diabetes who had recently suffered a stroke with testosterone undecanoate. During the acute phase of...
View ArticleLessons about Testosterone Therapy from the Testosterone Trials
The Testosterone Trials show that testosterone therapy confers significant and clinically meaningful health benefits in older men with low testosterone levels. Even though the Testosterone Trials aimed...
View ArticleMuscle and strength gains during testosterone therapy are greater with...
Does it matter which testosterone preparation is prescribed for testosterone therapy? This is a common question among HCPs as well as patients. A new meta-analysis shows that testosterone therapy with...
View ArticleMuscular responses to testosterone therapy vary by administration route -...
Does it matter which testosterone preparation is prescribed for testosterone therapy? This is a common question among HCPs as well as patients. A new meta-analysis shows that testosterone therapy with...
View ArticleLong-Term Treatment with Testosterone Undecanoate Improves Waist...
Due to a high prevalence of hypogonadism in type 2 diabetic men, current guidelines recommend to test for low levels of testosterone in diabetic men. A progressive reduction in waist circumference,...
View ArticleTestosterone therapy with Nebido shows superior long-term adherence compared...
A prerequisite for successful testosterone therapy is that the therapeutic testosterone target level of 15-30 nmol/mL is maintained long-term in order for symptom resolution and health benefits to...
View ArticleTestosterone therapy to prevent type 2 diabetes in men at risk - rationale
The “Testosterone 4 Diabetes Mellitus” study, also known as the T4DM trial, is a large study designed to find out if testosterone therapy combined with lifestyle intervention (Weight Watchers®) for 2...
View ArticleTestosterone Therapy in Men with Hypogonadism Prevents Progression from...
Type 2 diabetes is a costly disease that is highly prevalent among men with hypogonadism. Unless given testosterone therapy, these men often struggle to achieve glycemic targets.Many studies have shown...
View ArticleNebido® Treatment Tracker
The Nebido® Treatment Tracker is a tool designed to help HCPs improve patient adherence to Nebido treatment. The British Society for Sexual Medicine (BSSM) guideline recommends initiating testosterone...
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